MJ210

Product Specifications

Target

NF-?B|||Reactive Oxygen Species|||p38 MAPK|||ROS

Related Pathways

MAPK|||Metabolism|||NF-?B|||Immunology/Inflammation

Bioactivity

MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-?B and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 ?M MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.