Balomenib
Product Specifications
CAS Number
2939850-17-4
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
Balomenib is an inhibitor of the menin-MLL interaction, effectively blocking the men1-MLL4-43 interaction with an IC50 of less than 0.075 μM. It inhibits cell growth in MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM), and HEK293 (CC50 < 2 μM) cells. Balomenib also exhibits antitumor activity.
Smiles
C(N1CCC2(CN(C2)C=3C4=C(C=CC(CC(F)(F)F)=C4)N=CN3)CC1)C=5C(C)=C6C(=CC5)N(C[C@@H]7CNC(=O)CO7)C(C#N)=C6
Molecular Formula
C33H34F3N7O2
Molecular Weight
617.664
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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