GSK3-IN-10
Product Specifications
CAS Number
844441-56-1
Target
GSK-3, JNK, DYRK, Others, CDK, Wnt/beta-catenin
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Others, Stem Cells, Cytoskeletal Signaling
Bioactivity
GSK3-IN-10 (Compound 4) is a multi-target inhibitor primarily affecting GSK3α and GSK3β with IC50 values of 1.0 nM and 2.0 nM, respectively. It inhibits the activation of β-catenin, enhances neuronal survival, and provides protective effects against endoplasmic reticulum stress.
Smiles
O=C(NCC1CCOCC1)C2=NNC=C2NC(=O)C=3C(F)=CC=CC3F
Molecular Formula
C17H18F2N4O3
Molecular Weight
364.347
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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