α-Tubulin polymerization-IN-1
Product Specifications
Target
ROS|||Nrf2|||Microtubule Associated|||Apoptosis|||Reactive Oxygen Species
Related Pathways
Cytoskeletal Signaling|||NF-?B|||Apoptosis|||Metabolism|||Immunology/Inflammation
Bioactivity
?-Tubulin polymerization-IN-1 (Compound 8l) functions as an inhibitor of ?-tubulin polymerization. This compound modulates the NRF2/KEAP-1 signaling pathway and induces ROS production in PC-3 cells, leading to apoptosis. It inhibits the proliferation of PC-3 cells with a GI50 of 0.17 µM, causing cell cycle arrest in the G2/M phase. Additionally, ?-Tubulin polymerization-IN-1 demonstrates antitumor activity in mouse models.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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