Galectin-3-IN-6
Product Specifications
CAS Number
2604662-64-6
Target
Galectin
Related Pathways
Immunology/Inflammation
Bioactivity
Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and ?-smooth muscle actin (?SMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.
Smiles
O(C)[C@@H]1[C@H]([C@@H](O)[C@@H](CO)O[C@H]1C(N(C2=CC(Cl)=CC(Cl)=C2)[C@@H]3[C@@H](O)CCCC3)=O)N4C=C(N=N4)C5=CC(F)=C(F)C(F)=C5
Molecular Formula
C28H29Cl2F3N4O6
Molecular Weight
645.454
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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