EGFR-IN-151
Product Specifications
Target
EGFR|||ERK|||STAT|||Apoptosis
Related Pathways
JAK/STAT signaling|||Apoptosis|||Tyrosine Kinase/Adaptors|||MAPK|||Angiogenesis|||Stem Cells
Bioactivity
EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 ?M for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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