Antitumor agent-200
Product Specifications
CAS Number
3046118-64-0
Target
Microtubule Associated|||P-gp
Related Pathways
Cytoskeletal Signaling|||Neuroscience|||Membrane transporter/Ion channel
Bioactivity
Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.
Smiles
O=C(NCC1=CC=C([Se]C)C(O)=C1)C2=CC(F)=CC=C2N3CCOCC3
Molecular Formula
C19H21FN2O3Se
Molecular Weight
423.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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