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PDHK1-IN-2

Product Specifications

CAS Number

2870691-38-4

Target

Dehydrogenase

Related Pathways

Metabolism

Bioactivity

PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinase 1/2 (PDHK1/2), with an IC50 of 0.007 μM for PDHK1 and 0.015 μM for PDHK2. PDHK1-IN-2 has the potential to regulate immune cell metabolism and correct mitochondrial dysfunction, making it a promising candidate for research in autoimmune diseases, inflammatory conditions, and cancer.

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C(C)C1(C=2C(NC1=O)=C(NCC)C=C(F)C2)N3C[C@H](NC(=O)C4CC5(C4)CN(C#N)C5)CCC3

Molecular Formula

C25H33FN6O2

Molecular Weight

468.567

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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