PDHK1-IN-2
Product Specifications
CAS Number
2870691-38-4
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinase 1/2 (PDHK1/2), with an IC50 of 0.007 ?M for PDHK1 and 0.015 ?M for PDHK2. PDHK1-IN-2 has the potential to regulate immune cell metabolism and correct mitochondrial dysfunction, making it a promising candidate for research in autoimmune diseases, inflammatory conditions, and cancer.
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C(C)C1(C=2C(NC1=O)=C(NCC)C=C(F)C2)N3C[C@H](NC(=O)C4CC5(C4)CN(C#N)C5)CCC3
Molecular Formula
C25H33FN6O2
Molecular Weight
468.567
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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