JP-153
Product Specifications
CAS Number
1802937-26-3
Target
FAK|||Src
Related Pathways
Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Angiogenesis
Bioactivity
JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473) . JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
Smiles
O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C=3C=CC=4C=CC=CC4C3N1
Molecular Formula
C21H19NO5
Molecular Weight
365.379
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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