Mal-VC-PAB-EDA-N-Ac-Calicheamicin
Product Specifications
CAS Number
2028299-61-6
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a drug-linker conjugate for ADCs, exhibiting potent antitumor activity. OncoFAP-GlyPro-MMAF is composed of the ADC toxin Calicheamicin and a linker. It is used in the synthesis of the ADC molecule PF-06647263.
Smiles
CCN([C@H]1CO[C@H](C[C@@H]1OC)O[C@@H]2[C@H]([C@@H]([C@H](OC2O[C@H]3C#C/C=C\C#C[C@]\4(CC(=O)C(=C3/C4=C\CSSC(C)(C)CCC(=O)NCCNC(=O)OCC5=CC=C(C=C5)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CCCCCN6C(=O)C=CC6=O)NC(=O)OC)O)C)NO[C@H]7C[C@@H]([C@@H]([C@H](O7)C)SC(=O)C8=C(C(=C(C(=C8OC)OC)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)OC)O)I)C)O)O)C(=O)C
Molecular Formula
C93H128IN11O31S3
Molecular Weight
2119.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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