TIP48/49-IN-1
Product Specifications
CAS Number
1807337-58-1
Target
Proton pump
Related Pathways
Membrane transporter/Ion channel
Bioactivity
TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC) .
Smiles
O(CC)C1=C(C=2OC(=NN2)[C@@H]3C[C@H](C(NC=4C(=O)N(N(C)C4C)C5=CC=CC=C5)=O)CCC3)C=C(Cl)C=C1
Molecular Formula
C28H30ClN5O4
Molecular Weight
536.022
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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