AMG28
Product Specifications
CAS Number
1202764-07-5
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.
Smiles
OC(C#CC=1C=CC=2NC3=C(C=4N=C(N=CC4CCC3)N)C2C1)(C)C
Molecular Formula
C20H20N4O
Molecular Weight
332.399
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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