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P131

Product Specifications

CAS Number

2360561-66-4

Target

PROTAC Linker

Related Pathways

PROTAC

Bioactivity

P131 is a PROTAC molecule consisting of a cereblon ligand based on Pomalidomide and IBT6A, linked via a PEG linker. P131 effectively degrades both wild-type and C481S mutant BTK with nanomolar potency.

Smiles

NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(=O)C6=CN(CCOCCOCCOCCNC7=C8C(C(=O)N(C8=O)C9C(=O)NC(=O)CC9)=CC=C7)N=N6)CCC5)=NC=N1

Molecular Formula

C46H48N12O9

Molecular Weight

912.948

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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