Dirozalkib
Product Specifications
CAS Number
1893419-37-8
Target
ALK
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
Dirozalkib (Compound 4) is an ALK inhibitor with an IC50 of 0.9 nM. It demonstrates antiproliferative activity in cancer cells NCI-H3122, Karpas-299, and NCI-H2228, with IC50 values of 130.4, 0.71, and 15.11 nM, respectively. Dirozalkib exhibits favorable pharmacokinetic properties and a bioavailability ranging from 30% to 50%.
Smiles
O=S(=O)(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC=3C=C(C(=C4OCCOC43)C5CCNCC5)C)C(C)C
Molecular Formula
C27H32ClN5O4S
Molecular Weight
558.092
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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