What is the catalog number for YAP-IN-1?

The catalog number for YAP-IN-1 is T206234.

What sizes are available for YAP-IN-1?

YAP-IN-1 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does YAP-IN-1 come in?

YAP-IN-1 is available in 2 different pack sizes.

Is YAP-IN-1 in stock?

YAP-IN-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures YAP-IN-1?

YAP-IN-1 is manufactured by Molfinity.

What is the estimated delivery time for YAP-IN-1?

Estimated delivery time for YAP-IN-1 is approximately 10 business day(s), depending on your location.

YAP-IN-1

Product Specifications

Target

YAP

Related Pathways

Stem Cells

Bioactivity

YAP-IN-1 (Compound (+) -1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.