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Hyp-dBET1

Product Specifications

Target

Epigenetic Reader Domain|||PROTACs

Related Pathways

PROTAC|||Chromatin/Epigenetic

Bioactivity

Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 ?M in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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