Paeoniflorin-6′-O-benzene sulfonate
Product Specifications
CAS Number
1390658-79-3
Target
STAT, JAK, CXCR, Interleukin, GRK, TNF, IFNAR
Related Pathways
GPCR/G Protein, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Apoptosis, Autophagy, Immunology/Inflammation, Chromatin/Epigenetic, Angiogenesis, Stem Cells
Bioactivity
Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.
Smiles
C(OC(=O)C1=CC=CC=C1)[C@@]23[C@@]4(O[C@@H]5O[C@H](COS(=O)(=O)C6=CC=CC=C6)[C@@H](O)[C@H](O)[C@H]5O)[C@@]7(C)O[C@@]2(O[C@@](O)([C@@]3(C4)[H])C7)[H]
Molecular Formula
C29H32O13S
Molecular Weight
620.622
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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