CGS 24592
Product Specifications
CAS Number
147923-04-4
Target
Prolyl Endopeptidase (PREP)
Related Pathways
Proteases/Proteasome|||Metabolism
Bioactivity
CGS-24592 is an orally active, selective, and potent inhibitor of neutral endopeptidase 24.11 (NEP), with an IC50 value of 1.6 nmol/L. It reduces the degradation of atrial natriuretic peptide (ANP), thereby increasing plasma ANP concentration and lowering blood pressure. CGS-24592 shows potential for research in cardiovascular diseases such as hypertension and congestive heart failure.
Smiles
C([C@@H](C(NCCC(O)=O)=O)NCP(=O)(O)O)C1=CC=C(C=C1)C2=CC=CC=C2
Molecular Formula
C19H23N2O6P
Molecular Weight
406.37
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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