TREK inhibitor-3
Product Specifications
CAS Number
3023854-95-4
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
TREK inhibitor-3 (Cpd8l) is a selective inhibitor of TREK-1 that can cross the blood-brain barrier, with an IC50 of 0.81 ?M. It offers neuroprotective effects by significantly reducing cortical neuron death induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and alleviating brain injury in middle cerebral artery occlusion/reperfusion (MCAO/R) model mice. TREK inhibitor-3 is utilized in ischemic stroke research.
Smiles
O=C1OC(C2=CC=C(C=C12)C3CCNCC3)CC=4C=CC=CC4C
Molecular Formula
C21H23NO2
Molecular Weight
321.413
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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