RP-1664
Product Specifications
CAS Number
2980682-00-4
Target
PLK
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9904
Bioactivity
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. This compound demonstrates exceptional selectivity over related kinases, disrupts centriole biogenesis in cancer cells leading to PLK4 and p21 protein accumulation, shows enhanced sensitivity in TRIM37-high-expressing cells, and exhibits antitumor activity in breast cancer and neuroblastoma research.
Smiles
O=S(=O)(C1=CC(F)=C(C(F)=C1)N(C=2N=C(NC3=NNC(=C3)C)C(=C(N2)C=4N=CN(C4)C)C5CC5)C)C
Molecular Formula
C23H24F2N8O2S
Molecular Weight
514.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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