BQ0413

BQ0413 exhibits high affinity for PSMA, with a dissociation constant (KD) of 89 pM. It demonstrates effective uptake and internalization, with an internalization rate of 44% in PC3-pip cells. After being labeled with [99mTc], BQ0413 can serve as an imaging agent for tumors.

C([C@H](NC([C@H](CC1=CC=C(O)C=C1)NC(CCCCCCCNC([C@H](CCCCNC(CNC(C(NC(C(NC(C(NC(CS)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)=O)NC(C)=O)=O)=O)=O)C(NCCCC[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C2=CC3=C(C=C2)C=CC=C3