FTO-IN-14
Product Specifications
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
FTO-IN-14 (Compound F97) is an inhibitor of the RNA demethylase Fat mass and obesity-associated protein (FTO), with an IC50 of 0.45 μM. It modulates the expression of the ASB2, RARA, and MYC proteins. FTO-IN-14 demonstrates antiproliferative activity in AML cancer cells, with IC50 values of 0.7-5.5 μM against MOLM13, NB4, HEL, OCI-AML3, MV4-11, and MONOMAC6, and induces apoptosis in NB4 cells. Additionally, FTO-IN-14 exhibits antitumor activity in a mouse NB4 xenograft model.
Smiles
CC(NN=C1C)=C1C2=CC(C3CC3)=C(NC4=C(C(O)=O)SC=C4)C(C5CC5)=C2
Molecular Formula
C22H23N3O2S
Molecular Weight
393.502
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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