EXQ-2d
Product Specifications
Target
Wnt/beta-catenin, PARP
Related Pathways
Stem Cells, DNA Damage/DNA Repair, Cytoskeletal Signaling, Chromatin/Epigenetic
Bioactivity
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.
Molecular Formula
C18H17N3O3
Molecular Weight
323.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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