PT-129
Product Specifications
Target
GTPase
Related Pathways
GPCR/G Protein
Bioactivity
PT-129 is a PROTAC degrader targeting the NTF2 domain of G3BP1/2, capable of inhibiting and degrading stress granules in stressed cells, disrupting ATF4 trafficking, and suppressing fibroblast-mediated cancer cell proliferation.
Smiles
O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3NCCOCCOCCOCCC(NC4=CC=C(NC([C@H](CC5=CC=CC=C5)NS(=O)(CC(N6C(C=CC=C7)=C7C=N6)=O)=O)=O)C=C4)=O
Molecular Formula
C46H48N8O12S
Molecular Weight
936.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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