FXR agonist 12
Product Specifications
CAS Number
1831862-88-4
Target
FXR
Related Pathways
Metabolism
Bioactivity
FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.
Smiles
C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCC(O)=O)C)(CC4)[H])[H])([C@H](O)[C@H](CC)[C@@]1(CCCC2)[H])[H])[H]
Molecular Formula
C26H44O3
Molecular Weight
404.626
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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