FGFR2/3-IN-2
Product Specifications
CAS Number
3025799-28-1
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.
Smiles
O=C(N)C1=C2C=NC(=CN2C(C=3C=CC(=CC3)NC(=O)C(F)=C)=C1C4=CC=C(OC5=NC=CC(=N5)C)C=C4)C
Molecular Formula
C29H23FN6O3
Molecular Weight
522.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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