KWR137
Product Specifications
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.
Smiles
O=C1C(N2CCN(C(C3=CC(N=CC=C4)=C4N3)=O)CC2)=C(CC)N(CC(NC5=CC=C(C(F)(F)F)C=C5Cl)=O)C6=NC(C7=CCOCC7)=NN61
Molecular Formula
C33H31ClF3N9O4
Molecular Weight
710.105
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
![MIRO2 (RHOT2) Mouse Monoclonal Antibody [Clone ID: N384/63]](https://cdn.genprice.uk/products/937/68dd1898061270361e8fb4b0/imageurl/75-365.webp)
75-365 100 µL
MIRO2 (RHOT2) Mouse Monoclonal Antibody [Clone ID: N384/63]
Sign In for Pricing
View Details 
![Rabbit Polyclonal Septin-11 Antibody [Alexa Fluor 405]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
NBP2-32159AF405 0.1 mL
Rabbit Polyclonal Septin-11 Antibody [Alexa Fluor 405]
Sign In for Pricing
View Details MBS2084805-01 0.1 mL
PE-Linked Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b)
Sign In for Pricing
View Details 
MBS2084805-02 0.2 mL
PE-Linked Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b)
Sign In for Pricing
View Details