KWR137
Product Specifications
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.
Smiles
O=C1C(N2CCN(C(C3=CC(N=CC=C4)=C4N3)=O)CC2)=C(CC)N(CC(NC5=CC=C(C(F)(F)F)C=C5Cl)=O)C6=NC(C7=CCOCC7)=NN61
Molecular Formula
C33H31ClF3N9O4
Molecular Weight
710.105
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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