GE1111
Product Specifications
CAS Number
2883669-12-1
Target
MRGPR
Related Pathways
GPCR/G Protein
Bioactivity
GE1111 is an antagonist of the mas-related G protein-coupled receptor X2 (MRGPRX2), exhibiting an IC50 of 9.42 μM. It inhibits mast cell degranulation with an IC50 of 4.7 μM. In the C48/80-induced systemic allergic reaction model, GE1111 demonstrates both antiallergic and anti-inflammatory properties.
Smiles
O=CC1=CC=2C=C(C=C3C=CC(O)=C(C32)C1C)C4=CC=5C=CC(=CC5C=C4C(=O)OC)NC(=O)N
Molecular Formula
C28H22N2O5
Molecular Weight
466.485
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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