PROTAC cGAS degrader-1

PROTAC cGAS degrader-1 (Compound TH35) is a potent and selective cGAS PROTAC degrader, exhibiting DC50 values of 0.9 μM in THP-1 cells and 4.6 μM in RAW 264.7 cells. It effectively inhibits the activation of cGAS signaling induced by dsDNA. PROTAC cGAS degrader-1 also demonstrates anti-inflammatory properties, making it suitable for research into cGAS-related inflammatory diseases. (Pink: cGAS inhibitor; Black: Linker; Blue: E3 ligase ligand)