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PROTAC cGAS degrader-1

Product Specifications

Target

PROTACs|||cGAS

Related Pathways

Immunology/Inflammation|||PROTAC

Bioactivity

PROTAC cGAS degrader-1 (Compound TH35) is a potent and selective cGAS PROTAC degrader, exhibiting DC50 values of 0.9 ?M in THP-1 cells and 4.6 ?M in RAW 264.7 cells. It effectively inhibits the activation of cGAS signaling induced by dsDNA. PROTAC cGAS degrader-1 also demonstrates anti-inflammatory properties, making it suitable for research into cGAS-related inflammatory diseases. (Pink: cGAS inhibitor; Black: Linker; Blue: E3 ligase ligand)

Molecular Formula

C36H33Cl2N7O5

Molecular Weight

714.6

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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