Keap1-Nrf2-IN-25
Product Specifications
Target
Reactive Oxygen Species, Nrf2, ROS, Interleukin
Related Pathways
Metabolism, NF-κB, Immunology/Inflammation
Bioactivity
Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor with an IC50 of 0.55 μM and exhibits a Keap1 binding affinity (Kd of 0.50 μM) . This compound activates Nrf2, reducing reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6) . Additionally, Keap1-Nrf2-IN-25 provides protective effects against DSS-induced colitis.
Smiles
CC1=CC(=C(C(=C1)C)S(=O)(=O)N(CC(=O)O)C2=CC=C(C3=CC=CC=C32)N[C@@H](C)CC(=O)O)C
Molecular Formula
C25H28N2O6S
Molecular Weight
484.565
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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