AA-BR-157
Product Specifications
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
AA-BR-157 is a PROTAC degrader targeting metallothionein 2A (MT2A) with a DC50 of 190 nM. It downregulates DIAPH3, a protein involved in cytoskeletal and cellular movement regulation, inhibiting cell migration in MDA-MB-231 and U-87 MG cell lines. Additionally, AA-BR-157 modulates zinc homeostasis in MDA-MB-231 cells. (Pink: ligand for target protein MT2A ligand 1; Black: linker; Blue: ligand for VHL E3 ligase) .
Molecular Formula
C56H70N8O11S2
Molecular Weight
1095.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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