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10-SLF

Product Specifications

CAS Number

2765058-89-5

Target

FKBP|||PROTACs

Related Pathways

PROTAC|||Immunology/Inflammation|||Apoptosis|||Autophagy

Bioactivity

10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.

Smiles

C(N(CCCOCCOCCOCCCNC(COC1=CC([C@H](OC(=O)[C@H]2N(C(C(C(CC)(C)C)=O)=O)CCCC2)CCC3=CC(OC)=C(OC)C=C3)=CC=C1)=O)C(CCl)=O)(C(NCC4=CC=CC=C4)=O)C5=CC=C(Cl)C=C5

Molecular Formula

C59H76Cl2N4O13

Molecular Weight

1120.16

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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