DDO-8958
Product Specifications
CAS Number
3017180-18-3
Target
Epigenetic Reader Domain, Apoptosis
Related Pathways
Apoptosis, Chromatin/Epigenetic
Bioactivity
DDO-8958 is an orally active and selective BET BD1 inhibitor, exhibiting a KD of 5.6 nM for BRD4 BD1. It shows low nanomolar inhibitory activity across all BET BD1 bromodomains except for BRDT BD1. DDO-8958 inhibits tumor cell proliferation and migration, induces apoptosis and cell cycle arrest, and demonstrates antitumor activity.
Smiles
FC=1C(=CC(OCC2COC2)=CC1C=3C(=NN(C3C)C)C)C4=CC=NC=5N=CNC54
Molecular Formula
C22H22FN5O2
Molecular Weight
407.441
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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