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BRD4 degrader-5

Product Specifications

Target

Autophagy, AUTACs, Epigenetic Reader Domain

Related Pathways

PROTAC, Chromatin/Epigenetic, Autophagy

Bioactivity

BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM) . It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.

Molecular Formula

C35H42ClN7O2S

Molecular Weight

660.27

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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