DS-103
Product Specifications
Target
Parasite|||HDAC
Related Pathways
Microbiology/Virology|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 ?M, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 ?M. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 ?M and 1.47 ?M, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 ?M and 2.23 ?M. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.
Molecular Formula
C28H33N5O3
Molecular Weight
487.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/315447296886046722/T205596
Available Sizes
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