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SMARt751

Product Specifications

CAS Number

1616370-52-5

Target

Antibacterial

Related Pathways

Microbiology/Virology

Bioactivity

SMARt751 targets the transcriptional regulator VirS, inhibiting its ability to bind DNA, which in turn enhances the expression of the mymA operon and activates Ethionamide. This activation increases the antimicrobial efficacy of Ethionamide against Mycobacterium tuberculosis, and overcomes its resistance. Furthermore, SMARt751 augments Ethionamide's antibacterial activity in mouse models and reduces its effective dose. Additionally, SMARt751 can permeate the blood-brain barrier.

Smiles

O=C(N1CCC(C2=CC=C(F)C=C2)CC1)CCC(F)(F)F

Molecular Formula

C15H17F4NO

Molecular Weight

303.295

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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