SMARt751
Product Specifications
CAS Number
1616370-52-5
Target
Antibacterial
Related Pathways
Microbiology/Virology
Bioactivity
SMARt751 targets the transcriptional regulator VirS, inhibiting its ability to bind DNA, which in turn enhances the expression of the mymA operon and activates Ethionamide. This activation increases the antimicrobial efficacy of Ethionamide against Mycobacterium tuberculosis, and overcomes its resistance. Furthermore, SMARt751 augments Ethionamide's antibacterial activity in mouse models and reduces its effective dose. Additionally, SMARt751 can permeate the blood-brain barrier.
Smiles
O=C(N1CCC(C2=CC=C(F)C=C2)CC1)CCC(F)(F)F
Molecular Formula
C15H17F4NO
Molecular Weight
303.295
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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