BKCa activator-1
Product Specifications
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.
Smiles
FC1=C(F)C(OC2=CC=C(NCCCCCN3CCOCC3)C=C2O)=C(F)C(F)=C1C(F)(F)F
Molecular Formula
C22H23F7N2O3
Molecular Weight
496.418
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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