BRD6257
Product Specifications
Target
Phosphatase, MDM-2/p53
Related Pathways
Apoptosis, Metabolism
Bioactivity
BRD6257 is an orally active inhibitor of protein phosphatase 1D (proteinphosphatase, Mg2+/Mn2+ dependent 1D, PPM1D) with an IC50 of 5 nM. It activates the p53 signaling pathway (EC50 of 51 nM), enhances p21 expression, and inhibits the proliferation of cancer cells MOLM13 (IC50 = 2.8 μM) . BRD6257 demonstrates good metabolic stability in human and rat liver microsomes.
Molecular Formula
C24H22F4N6O3S
Molecular Weight
550.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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