SOS1-IN-18
Product Specifications
Target
Ras|||Raf|||ERK
Related Pathways
GPCR/G Protein|||MAPK
Bioactivity
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.
Molecular Formula
C26H29F3N4O2
Molecular Weight
486.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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