MKLP2-IN-1
Product Specifications
CAS Number
2929345-46-8
Target
Kinesin
Related Pathways
Cytoskeletal Signaling
Bioactivity
MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.
Smiles
O=C1N(C=2C=CC=CC2C(Br)=C(C3=NN=C(O3)C4CC4)C1)CC5=CC=C(C(F)=C5)C
Molecular Formula
C23H19BrFN3O2
Molecular Weight
468.318
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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