Dyrk1A-IN-12
Product Specifications
CAS Number
2243701-11-1
Target
Enterovirus, DYRK, Virus Protease
Related Pathways
Microbiology/Virology, Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint
Bioactivity
Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A) . It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV) .
Smiles
O=C(NC1=CN=CC(=C1)C=2SC=C(C2)C=3C=NC=CC3)C4=CC(OC)=CC=C4F
Molecular Formula
C22H16FN3O2S
Molecular Weight
405.445
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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