NLRP3-IN-70
Product Specifications
CAS Number
1997362-01-2
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.
Smiles
O=C1C(=O)C2=C(C=CC3=C2CCCC3(C)C)C=4OC=C(C(=O)N5CCOCC5)C14
Molecular Formula
C23H23NO5
Molecular Weight
393.432
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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