TrxR/EGFR-IN-1
Product Specifications
CAS Number
3038386-42-1
Target
EGFR, Ferroptosis, Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis, Angiogenesis
Bioactivity
TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.
Smiles
FC1=CC=C(C=C1Cl)NC=2N=CN=C3C=C(OC)C(OCC#[C-][Au+][P]45CN6CN(CN(C6)C4)C5)=CC32
Molecular Formula
C24H24AuClFN6O2P
Molecular Weight
710.878
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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