BRD4 Inhibitor-40
Product Specifications
CAS Number
2994635-04-8
Target
Epigenetic Reader Domain|||c-Myc
Related Pathways
Chromatin/Epigenetic|||Cell Cycle/Checkpoint
Bioactivity
BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.
Smiles
C(C)(C)N1C=2C(=CC=C(NC=3N=C(NC=4C=5C(N(C)N4)=CC=CC5)C=C(CC)N3)C2)N(C)C(=O)[C@H]1C
Molecular Formula
C27H32N8O
Molecular Weight
484.596
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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