Hsp90-IN-38
Product Specifications
CAS Number
3065556-04-6
Target
HSP|||ATPase
Related Pathways
Cytoskeletal Signaling|||Membrane transporter/Ion channel|||Metabolism
Bioactivity
Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein) . It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 ?M. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 ?M, respectively.
Smiles
C(=O)(N1[C@@H](C(NCCCN2CCOCC2)=O)C[C@@H](C1)C3=CC=CC=C3)C4=CC(=C(O)C=C4O)C5CC5
Molecular Formula
C28H35N3O5
Molecular Weight
493.595
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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