BF-170
Product Specifications
CAS Number
22191-97-5
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
BF-170 is a selective tau fiber-binding agent with an EC50 of 221 nM. It demonstrates excellent blood-brain barrier penetration, reaching a concentration of 9.1% ID/g in brain tissue 2 minutes after intravenous injection in mice (with a clearance rate of 0.25% ID/g at 30 minutes) . BF-170 can serve as a probe for imaging tau protein pathology in Alzheimer's disease (AD) . It plays a significant role in early-stage Alzheimer's disease studies and holds promise for imaging research in tau-related neurodegenerative diseases.
Smiles
N=1C=2C=CC=CC2C=CC1C=3C=CC(N)=CC3
Molecular Formula
C15H12N2
Molecular Weight
220.269
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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